As a leading provider of rheumatology services in Central Texas, Central Texas Rheumatology Associates understands the importance of educating our patients about their conditions. In this blog post, we will delve into the causes of rheumatoid arthritis (RA), shedding light on the factors that contribute to the development of this chronic autoimmune disease.
What Causes Rheumatoid Arthritis?
What Causes Rheumatoid Arthritis?
Genetic Factors
Genetic predisposition seems to be a key contributor to the development of RA. Certain genes, such as the HLA-DRB1 gene, can be linked to a higher likelihood of developing the disease. However, having these genes does not guarantee that an individual will develop RA. It merely increases their susceptibility.
Environmental Triggers
Various environmental factors can trigger the onset of RA in genetically susceptible individuals. These triggers include cigarette smoking, infections, and hormonal changes. Smoking, in particular, is strongly associated with an increased risk of developing RA. Research indicates that smoking affects the immune system and promotes the production of antibodies that attack healthy tissues, leading to inflammation.
Immunological Dysfunction
RA occurs due to an abnormal immune response where the body's immune system mistakenly attacks healthy joint tissues. This immune dysfunction results in chronic inflammation, damaging the synovial lining of the joints and surrounding tissues. The reasons for this autoimmune response are not completely understood, but it is believed to be a combination of genetic and environmental factors triggering the immune system to attack healthy tissues.
Gender and Hormonal Factors
Women tend to be more prone to developing RA than men, suggesting a potential hormonal influence. The presence of biological markers, such as estrogen, may contribute to the higher prevalence in women. Hormonal changes, such as those occurring during pregnancy or menopause, can also affect the severity of symptoms experienced by individuals with RA.
While the exact cause of rheumatoid arthritis is yet to be fully understood, it is clear that a combination of factors all play a role in its development. At Central Texas Rheumatology Associates, our dedicated team of autoimmune specialists is committed to providing comprehensive care based on the latest scientific advancements, ensuring the best possible outcomes for our patients living with RA. Contact us to schedule an appointment at our Cedar Park or West Lake Hills location!